Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle stimulating hormone inhibiting substance in ovarian follicular fluid.
Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an Nterminal atypical TGF binding domain, three Follistatin domains that contain EGF-like and kazal-like motifs, and a highly acidic Cterminal tail.
Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors.
It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin 315 is a 34.7 kDa protein containing amino acids 30-344 of the FST-315 protein.
Follistatin-315 Recent animal studies, which were completed in 2009, have suggested that regulation of Follistatin on the genetic level may deliver significant outcomes in the increase of muscle mass and muscle strength. Consequently, from 2009 the product was introduced for the use with humans and there have been cases when daily injection of 100 mcg of Follistatin-315 led in individuals with body weight of 86 to 87 kg to muscle gain of approx. 5 kg over the period of 10 days.
The Follistatin-315 peptide has also a substantial effect on the tissue rejuvenation. Its significant anti-aging effect is comparable to the one delivered by Melatonin or other peptides that play a positive role in the anti-aging process.
The Follistatin production decreases with age, which on the other hand increases side effects of Myostatin. Besides the ability to inhibit the muscle growth, Myostatin can regenerate cells within the adipose tissue, as well. For regenerative processes the body starts to utilize its own endogenous proteins and amino acids and as a result, the final count of muscle fibres significantly decreases and keeps decreasing with age. This is the reason why elderly people become “overweight and obese” (they accumulate fat) and thus have a lack of muscle mass.
The effects of Follistatin-315:
Follistatin-315 significantly increases muscle growth and muscle strength (by blocking the Moystatin activity) – it promotes hyperplasia (growth of new muscle cells) as well as active hypertrophy (increase in cell size).
Follistatin-315 exhibits a potent anabolic activity (yet without concomitant androgenic activity). Taking Follistatin-315 results in muscular hyperplasia (growth of new muscle fibres) and active hypertrophy (increase in size of existing muscle fibres)
Follistatin-315 has a strong ability to keep sportsmen in shape and maintain their muscle mass even when they stopped exercising
Follistatin-315 significantly increases performance
Follistatin-315 exhibits a potent anti-aging effect, with a significant impact on rejuvenation of all body tissues
Follistatin-315 promotes body´s fat burning
The recommended dosing of Follistatin-315
Follistatin-315 should be taken in a dose of 100 to 200 mcg minimun once per day, for the period of 15-30 days.
Follistatin-315 is not intended for use by women